Efficacy of a New Therapeutic Regimen Versus Two Routinely Prescribed Treatments for Eradication of Helicobacter Pylori: A Randomized, Double-Blind Study of …
Digestive diseases and sciences, 2009•Springer
This study compared a new regimen (group A: doxycycline, co-amoxiclav, omeprazole) and
two routinely prescribed regimens (group B: amoxicillin, omeprazole, furazolidone, bismuth;
group C: amoxicillin, clarithromycin, omeprazole) to find an acceptable first-line treatment
option for Helicobacter pylori. The study population consisted of 189 patients who referred to
our clinic to undergo endoscopy due to ulcer-like dyspepsia. The H. pylori eradication rate
was 68% in group A, 56% in group B, and 70% in group C according to per-control analysis …
two routinely prescribed regimens (group B: amoxicillin, omeprazole, furazolidone, bismuth;
group C: amoxicillin, clarithromycin, omeprazole) to find an acceptable first-line treatment
option for Helicobacter pylori. The study population consisted of 189 patients who referred to
our clinic to undergo endoscopy due to ulcer-like dyspepsia. The H. pylori eradication rate
was 68% in group A, 56% in group B, and 70% in group C according to per-control analysis …
Abstract
This study compared a new regimen (group A: doxycycline, co-amoxiclav, omeprazole) and two routinely prescribed regimens (group B: amoxicillin, omeprazole, furazolidone, bismuth; group C: amoxicillin, clarithromycin, omeprazole) to find an acceptable first-line treatment option for Helicobacter pylori. The study population consisted of 189 patients who referred to our clinic to undergo endoscopy due to ulcer-like dyspepsia. The H. pylori eradication rate was 68% in group A, 56% in group B, and 70% in group C according to per-control analysis. There was no statistically significant difference in H. pylori eradication between groups A and B (P = 0.187), groups A and C (P = 0.857), and groups B and C (P = 0.15). In conclusion, although none of the three eradication regimens can be recommended as a first-line eradication treatment, the new regimen is at least as effective and probably better tolerated than the two routinely applied regimens.
Springer
